The main symptom of pyoderma gangrenosum is a large, painful ulcer on your skin.
It usually starts as a small bump, spot or blood blister that gets bigger quickly and turns into an ulcer.
Sometimes you may have more than 1 ulcer.
Pyoderma gangrenosum ulcers:
On brown or black skin, the skin around the pyoderma gangrenosum ulcer may be darker than the rest of the skin.
Other symptoms include:
Other conditions can have similar symptoms to pyoderma gangrenosum, such as venous leg ulcers, injuries to the skin, insect bites, skin tumours or infection.
Do not try to diagnose the problem yourself. See a GP if you're worried.
How pyoderma gangrenosum is treated depends on how severe it is.
It can take a long time for the ulcers to heal and you may have scars.
Treatment may include:
Rarely, you may need surgery remove the ulcers.
It's not always clear what causes pyoderma gangrenosum. It may be an autoimmune disease, where the body's natural defence system (immune system) attacks healthy parts of your body.
It can also sometimes happen after an injury to the skin.
You may be more likely to get pyoderma gangrenosum if you have certain conditions, including:
You may also be more likely to get pyoderma gangrenosum if you take certain medicines.